The Biomedical Engineering group in the Department of Electrical Engineering invites applicants for a 3-year PhD Position.
Hyperpolarized Metabolic Magnetic Resonance (MR) is an exciting new method for the non-invasive study of in vivo biochemistry in real time. In this project the aim is to develop a method for non-invasive imaging of pH and redox potential through two new hyperpolarized substrates, 13C-bicarbonate and 13C-ascorbic acid, and study the relevance of these parameters in tumor progression and treatment.
This PhD study will focus on the technical aspects of developing the methods, and will run in parallel with a PhD study that focuses on the biology. Specifically, optimal formulations of 13C-bicarbonate and [1-13C] dehydroascorbic acid will be developed to maximize the concentration and polarization. Secondly, to develop optimal imaging methods for mapping of pH and redox by taking advantage of the specific MR properties of 13C-bicarbonate/13CO2 and [1-13C]dehydroascorbic acid/[1-13C]ascorbic acid. Today there is no other method that can image non-invasively the tissue pH and redox potential.
The successsful candidate should have a solid background in MR spectroscopy or imaging, as well as a good understanding of chemistry and physical chemistry. The work will be shared between the lab at DTU and Hvidovre Hospital. Hyperpolarization and chemistry studies will take place at DTU, whereas Hvidovre Hospital (Danish Research Centre for Magnetic Resonance) has facilities for hyperpolarization and imaging of small animals.
Starting Date 1 October 2013
Qualifications: Candidates should have a MSc in engineering or a similar degree with an academic level equivalent to the MSc in engineering.
Approval and Enrolment: PhD Scholarships are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide. http://www.dtu.dk/English/education/Phd_Education/PhD_guide.aspx
Assessment: The assessment of the applicants will be made by Jan Ardenkjær-Larsen.
We Offer: We offer an interesting and challenging job in an international environment focusing on education, research, public-sector consultancy and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.
Salary and Appointment Terms: The salary and appointment terms are consistent with the current rules for PhD students. The period of employment is 3 years.
Further Information: Further information may be obtained from Jan Ardenkjær-Larsen, tel: +45 40 27 27 75.
Application: Please submit your online application no later than 30 September 2013. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link “Apply online,” fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
A letter Motivating the Application (Cover Letter)
- Curriculum vitae
- Grade transcripts and BSc/MSc diploma
- Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here) http://www.dtu.dk/english/Education/phd/Applicant/Pre_acceptance%281%29
Candidates may apply prior to obtaining their MSc, but cannot begin before having received it.
All qualified candidates irrespective of age, gender, race, inability, religion or ethnic background are encouraged to apply.
Application Deadline: 30 September 2013